Adonis Diaries

Archive for August 16th, 2015

Has Brain-to-brain communication arrived?

On June 12, 2014, precisely at 3:33 in a balmy winter afternoon in São Paulo, Brazil, a typical South American winter afternoon, this kid, this young man that you see celebrating here like he had scored a goal, Juliano Pinto, 29 years old, accomplished a magnificent deed.

Despite being paralyzed and not having any sensation from mid-chest to the tip of his toes as the result of a car crash six years ago that killed his brother and produced a complete spinal cord lesion that left Juliano in a wheelchair, Juliano rose to the occasion, and on this day did something that pretty much everybody that saw him in the six years deemed impossible. Juliano Pinto delivered the opening kick of the 2014 Brazilian World Soccer Cup here just by thinking.

He could not move his body, but he could imagine the movements needed to kick a ball. He was an athlete before the lesion.

He’s a para-athlete right now. He’s going to be in the Paralympic Games, I hope, in a couple years. But what the spinal cord lesion did not rob from Juliano was his ability to dream.

And dream he did that afternoon, for a stadium of about 75,000 people and an audience of close to a billion watching on TV.

1:53 And that kick crowned, basically, 30 years of basic research studying how the brain, how this amazing universe that we have between our ears that is only comparable to universe that we have above our head because it has about 100 billion elements talking to each other through electrical brainstorms, what Juliano accomplished took 30 years to imagine in laboratories and about 15 years to plan.

When John Chapin and I, 15 years ago, proposed in a paper that we would build something that we called a brain-machine interface, meaning connecting a brain to devices so that animals and humans could just move these devices, no matter how far they are from their own bodies, just by imagining what they want to do, our colleagues told us that we actually needed professional help, of the psychiatry variety.

And despite that, a Scot and a Brazilian persevered, because that’s how we were raised in our respective countries, and for 15 years, we made demonstration after demonstration suggesting that this was possible.

And a brain-machine interface is not rocket science, it’s just brain research.

It’s nothing but using sensors to read the electrical brainstorms that a brain is producing to generate the motor commands that have to be downloaded to the spinal cord, so we projected sensors that can read hundreds and now thousands of these brain cells simultaneously, and extract from these electrical signals the motor planning that the brain is generating to actually make us move into space.

And by doing that, we converted these signals into digital commands that any mechanical, electronic, or even a virtual device can understand so that the subject can imagine what he, she or it wants to make move, and the device obeys that brain command.

By sensorizing these devices with lots of different types of sensors, as you are going to see in a moment, we actually sent messages back to the brain to confirm that that voluntary motor will was being enacted, no matter where — next to the subject, next door, or across the planet.

And as this message gave feedback back to the brain, the brain realized its goal: to make us move. So this is just one experiment that we published a few years ago, where a monkey, without moving its body, learned to control the movements of an avatar arm, a virtual arm that doesn’t exist. What you’re listening to is the sound of the brain of this monkey as it explores three different visually identical spheres in virtual space.

And to get a reward, a drop of orange juice that monkeys love, this animal has to detect, select one of these objects by touching, not by seeing it, by touching it, because every time this virtual hand touches one of the objects, an electrical pulse goes back to the brain of the animal describing the fine texture of the surface of this object, so the animal can judge what is the correct object that he has to grab, and if he does that, he gets a reward without moving a muscle. The perfect Brazilian lunch: not moving a muscle and getting your orange juice.

5:21 So as we saw this happening, we actually came and proposed the idea that we had published 15 years ago. We reenacted this paper. We got it out of the drawers, and we proposed that perhaps we could get a human being that is paralyzed to actually use the brain-machine interface to regain mobility.

The idea was that if you suffered — and that can happen to any one of us. Let me tell you, it’s very sudden. It’s a millisecond of a collision, a car accident that transforms your life completely.

If you have a complete lesion of the spinal cord, you cannot move because your brainstorms cannot reach your muscles.

However, your brainstorms continue to be generated in your head. Paraplegic, quadriplegic patients dream about moving every night. They have that inside their head. The problem is how to get that code out of it and make the movement be created again.

 So what we proposed was, let’s create a new body. Let’s create a robotic vest.

And that’s exactly why Juliano could kick that ball just by thinking, because he was wearing the first brain-controlled robotic vest that can be used by paraplegic, quadriplegic patients to move and to regain feedback.

That was the original idea, 15 years ago.

What I’m going to show you is how 156 people from 25 countries all over the five continents of this beautiful Earth, dropped their lives, dropped their patents, dropped their dogs, wives, kids, school, jobs, and congregated to come to Brazil for 18 months to actually get this done.

Because a couple years after Brazil was awarded the World Cup, we heard that the Brazilian government wanted to do something meaningful in the opening ceremony in the country that reinvented and perfected soccer until we met the Germans, of course. (Laughter)

But that’s a different talk, and a different neuroscientist needs to talk about that.

But what Brazil wanted to do is to showcase a completely different country, a country that values science and technology, and can give a gift to millions, 25 million people around the world that cannot move any longer because of a spinal cord injury.

Well, we went to the Brazilian government and to FIFA and proposed, let’s have the kickoff of the 2014 World Cup be given by a Brazilian paraplegic using a brain-controlled exoskeleton that allows him to kick the ball and to feel the contact of the ball. They looked at us, thought that we were completely nuts, and said, “Okay, let’s try.” We had 18 months to do everything from zero, from scratch.

We had no exoskeleton, we had no patients, we had nothing done.

These people came all together and in 18 months, we got 8 patients in a routine of training and basically built from nothing this guy, that we call Bra-Santos Dumont 1.

The first brain-controlled exoskeleton to be built was named after the most famous Brazilian scientist ever, Alberto Santos Dumont, who, on October 19, 1901, created and flew himself the first controlled airship on air in Paris for a million people to see. Sorry, my American friends, I live in North Carolina, but it was two years before the Wright Brothers flew on the coast of North Carolina. (Applause) Flight control is Brazilian. (Laughter)

So we went together with these guys and we basically put this exoskeleton together, 15 degrees of freedom, hydraulic machine that can be commanded by brain signals recorded by a non-invasive technology called electroencephalography that can basically allow the patient to imagine the movements and send his commands to the controls, the motors, and get it done.

This exoskeleton was covered with an artificial skin invented by Gordon Cheng, one of my greatest friends, in Munich, to allow sensation from the joints moving and the foot touching the ground to be delivered back to the patient through a vest, a shirt. It is a smart shirt with micro-vibrating elements that basically delivers the feedback and fools the patient’s brain by creating a sensation that it is not a machine that is carrying him, but it is he who is walking again.

We got this going, and what you’ll see here is the first time one of our patients, Bruno, actually walked. And he takes a few seconds because we are setting everything, and you are going to see a blue light cutting in front of the helmet because Bruno is going to imagine the movement that needs to be performed, the computer is going to analyze it, Bruno is going to certify it, and when it is certified, the device starts moving under the command of Bruno’s brain.

And he just got it right, and now he starts walking.

After 9 years without being able to move, he is walking by himself. And more than just walking, he is feeling the ground, and if the speed of the exo goes up, he tells us that he is walking again on the sand of Santos, the beach resort where he used to go before he had the accident. That’s why the brain is creating a new sensation in Bruno’s head.

So he walks, and at the end of the walk — I am running out of time already — he says, “You know, guys, I need to borrow this thing from you when I get married, because I wanted to walk to the priest and see my bride and actually be there by myself. Of course, he will have it whenever he wants.

And this is what we wanted to show during the World Cup, and couldn’t, because for some mysterious reason, FIFA cut its broadcast in half.

What you are going to see very quickly is Juliano Pinto in the exo doing the kick a few minutes before we went to the pitch and did the real thing in front of the entire crowd, and the lights you are going to see just describe the operation.

Basically, the blue lights pulsating indicate that the exo is ready to go. It can receive thoughts and it can deliver feedback, and when Juliano makes the decision to kick the ball, you are going to see two streams of green and yellow light coming from the helmet and going to the legs, representing the mental commands that were taken by the exo to actually make that happen.

And in basically 13 seconds, Juliano actually did. You can see the commands. He gets ready, the ball is set, and he kicks. And the most amazing thing is, 10 seconds after he did that, and looked at us on the pitch, he told us, celebrating as you saw, “I felt the ball.” And that’s priceless. (Applause)

Where is this going to go? I have two minutes to tell you that it’s going to the limits of your imagination.

Brain-actuating technology is here. This is the latest: We just published this a year ago, the first brain-to-brain interface that allows two animals to exchange mental messages so that one animal that sees something coming from the environment can send a mental SMS, a torpedo, a neurophysiological torpedo, to the second animal, and the second animal performs the act that he needed to perform without ever knowing what the environment was sending as a message, because the message came from the first animal’s brain.

13:08 So this is the first demo. I’m going to be very quick because I want to show you the latest. But what you see here is the first rat getting informed by a light that is going to show up on the left of the cage that he has to press the left cage to basically get a reward. He goes there and does it. And the same time, he is sending a mental message to the second rat that didn’t see any light, and the second rat, in 70% of the times is going to press the left lever and get a reward without ever experiencing the light in the retina.

13:44 Well, we took this to a little higher limit by getting monkeys to collaborate mentally in a brain net, basically to donate their brain activity and combine them to move the virtual arm that I showed you before, and what you see here is the first time the two monkeys combine their brains, synchronize their brains perfectly to get this virtual arm to move. One monkey is controlling the x dimension, the other monkey is controlling the y dimension.

But it gets a little more interesting when you get three monkeys in there and you ask one monkey to control x and y, the other monkey to control y and z, and the third one to control x and z, and you make them all play the game together, moving the arm in 3D into a target to get the famous Brazilian orange juice. And they actually do.

The black dot is the average of all these brains working in parallel, in real time. That is the definition of a biological computer, interacting by brain activity and achieving a motor goal.

14:52 Where is this going? We have no idea. We’re just scientists. (Laughter)

We are paid to be children, to basically go to the edge and discover what is out there. But one thing I know: One day, in a few decades, when our grandchildren surf the Net just by thinking, or a mother donates her eyesight to an autistic kid who cannot see, or somebody speaks because of a brain-to-brain bypass, some of you will remember that it all started on a winter afternoon in a Brazilian soccer field with an impossible kick.


15:58 Bruno Giussani: Miguel, thank you for sticking to your time. I actually would have given you a couple more minutes, because there are a couple of points we want to develop, and, of course, clearly it seems that we need connected brains to figure out where this is going. So let’s connect all this together. So if I’m understanding correctly, one of the monkeys is actually getting a signal and the other monkey is reacting to that signal just because the first one is receiving it and transmitting the neurological impulse.

Miguel Nicolelis: No, it’s a little different. No monkey knows of the existence of the other two monkeys. They are getting a visual feedback in 2D, but the task they have to accomplish is 3D. They have to move an arm in three dimensions. But each monkey is only getting the two dimensions on the video screen that the monkey controls. And to get that thing done, you need at least two monkeys to synchronize their brains, but the ideal is three. So what we found out is that when one monkey starts slacking down, the other two monkeys enhance their performance to get the guy to come back, so this adjusts dynamically, but the global synchrony remains the same.

Now, if you flip without telling the monkey the dimensions that each brain has to control, like this guy is controlling x and y, but he should be controlling now y and z, instantaneously, that animal’s brain forgets about the old dimensions and it starts concentrating on the new dimensions.

So what I need to say is that no Turing machine, no computer can predict what a brain net will do. So we will absorb technology as part of us. Technology will never absorb us. It’s simply impossible.

BG: How many times have you tested this? And how many times have you succeeded versus failed?

MN: Oh, tens of times. With the three monkeys? Oh, several times. I wouldn’t be able to talk about this here unless I had done it a few times.

And I forgot to mention, because of time, that just three weeks ago, a European group just demonstrated the first man-to-man brain-to-brain connection.

BG: And how does that play?

MN: There was one bit of information — big ideas start in a humble way — but basically the brain activity of one subject was transmitted to a second object, all non-invasive technology.

So the first subject got a message, like our rats, a visual message, and transmitted it to the second subject. The second subject received a magnetic pulse in the visual cortex, or a different pulse, two different pulses. In one pulse, the subject saw something. On the other pulse, he saw something different. And he was able to verbally indicate what was the message the first subject was sending through the Internet across continents.


Patsy Z shared this link TED

Incredible new science allows monkeys to send thoughts straight into each other’s brains. And this is only the beginning…

Neuroscientist Miguel Nicolelis built the brain-controlled exoskeleton that allowed a paralyzed man to kick the first ball of the 2014 World Cup.|By Miguel Nicolelis

 A leadership issue at UBC board of governors? Dr. Nassif Ghoussoub wants John Montalbano  to resign as chair

I have been a faculty member at UBC for 38 years, and I have served this great university in many other functions, including six years on the Board of Governors (2008-14), three of them on the Board’s Management Resources Compensation Committee (MRCC).

I was elected by the faculty to the presidential search committee, which eventually chose Arvind Gupta, after evaluating hundreds of files during an eight-month deliberation period. You were also a key member of that committee, as Chair of the Board.

Last Friday, I read your joint announcement with the Chancellor, informing the world that President Gupta has decided to resign after only 13 months on the job. This news took many of us by surprise, as would be expected. What was not expected is that you, the Chair of the Board, were also “surprised” by this resignation, at least according to the Vancouver Sun.

This could only indicate that you, Mr. Chair, have erred, either in hiring Gupta, or in not anticipating the crisis, reading the situation, and providing the support you and the chancellor were expected to provide, so as to ensure that the president is successful.

Frankly, your botched announcement has caused disrepute to our university. The lack of clarity and the suspicious timing have triggered rumors and innuendos that, frankly, UBC can live without. You don’t seem to be aware that “an early lack of transparency and full communications can heighten the risk of a major crisis erupting.” And this eruption is happening now, under your watch.

You seem to have been taken off-guard by the Faculty Association’s request for clarity on the situation. Surprisingly, now you say that the full Board needs to confer, after the fact, to prepare answers. You seem to have failed to understand that ours is an institution that thrives on collegiality and respect across all of its stakeholders, and that its leadership must embrace the basic principles of shared governance.

Your understanding of university leadership and transitions is perplexing. We don’t hold our heads high when “Inside Higher Education” reports to the whole academic world: “When Mr. Montalbano suggested in the Globe & Mail that a university president is de-facto as disposable as a Swiffer Duster, it made me wonder if something else is going on and if risks are being taken with the future of my alma mater.”

This type of understanding may have led you to direct UBC into this unfortunate state of affairs. For one, the impact on the faculty was demoralizing. To them Gupta was a breath of fresh air, and their outcry reflects their high expectations from a president who valued their opinion, recognized their core academic values, and committed his support for their vision of excellence.

You must be aware that the last presidential search, inauguration, and transition costs alone are counted in the millions of dollars. Have you led the Board to ponder the massive financial waste of taxpayers’ money associated with all the personnel changes that accompany three presidential appointments in just over two years? Did you discuss the loss of momentum and reputational damage to an institution that will be dealing with a prolonged period of unstable, incoherent, and unfocused management?

Martha Piper’s message to the community speaks of the continuation of Gupta’s reforms and strategic plan. This indicates that this situation was not prompted by the president’s bold vision, but by an operational environment that you, the chancellor and the Board are supposed to oversee and keep honest.

One case in point is the brouhaha that is linking Gupta’s resignation to the departure of 3 Vice-presidents from the previous administration. From my own experience on the Board, such personnel changes are pre-approved by the MRCC, on which you and the chancellor sit. Have you given the president the support he needed, when these changes started making the news?

PSE historians relate that the most common factors that derail even the most visionary of presidencies are inordinate levels of interference by Board members on the president’s operational space, end-runs by deans and other subordinates trying to appeal directly to Governors, and an environment of extreme stress often caused by continuous harassment that can happen at any level of responsibility.

Did the Board debrief the president to learn if any of the above led to this short-lived presidency, and whether you and the chancellor have performed as expected to prevent such situations in your role as a key support to the president? I ask you because, if these issues are left unattended, no future president of UBC will be able to succeed, and the current impasse will be back soon to haunt us again.

A failure of a president is also reflective of the performance and the failure of the Board Chair, especially when the latter has both actively participated in the selection and convincingly shepherded the appointment through the Board. My question is therefore: Given the impasse we are currently facing, what guarantees UBC that your leadership will lead us to the right person next time around?

You often said in public and in private that you and Gupta are “brothers in arms. He fails, I fail.” Now that President Gupta has stepped down, unable to carry-on with his mission, it seems fitting that you, Sir, should do the same.

Nassif Ghoussoub is a professor of mathematics and a former member of the board of governors at UBC. This article originally appeared on his blog.




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